The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2001
Filed:
Sep. 29, 1998
Barbara A. Gilchrest, Boston, MA (US);
Mina Yaar, Sharon, MA (US);
Trustees of Boston University, Boston, MA (US);
Abstract
Methods of inhibiting &bgr;-amyloid-mediated activation of the p75 nerve growth factor receptor of a cell that expresses the p75 nerve growth factor receptor are provided. Methods of inhibiting the binding of &bgr;-amyloid protein and &bgr;-amyloid peptides to the p75 nerve growth factor receptor, and methods of inhibiting &bgr;-amyloid-mediated apoptosis of neural crest-derived cells are provided. The methods comprise contacting the cell with a substance, comprising, for example, the amino acid sequence lysine-glycine-lysine (KGK) or lysine-glycine-alanine (KGA), wherein the substance binds to the p75 nerve growth factor receptor, resulting in the inhibition of &bgr;-amyloid protein or &bgr;-amyloid peptide binding to and/or activation of the p75 nerve growth factor receptor, or wherein the substance inhibits &bgr;-amyloid protein or &bgr;-amyloid peptide mediated apoptosis of the cell which expresses the p75 nerve growth factor receptor.