The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2001
Filed:
Mar. 04, 1999
Franz Rieser, Wiesendangen, CH;
Werner Muller, Wiesendangen, CH;
Pedro Bittmann, Zurich, CH;
Pierre Mainil-Varlet, Bern, CH;
Christoph P. Saager, Frieswil, CH;
Sulzer Orthopedics Ltd., Winterthur, CH;
Abstract
Cartilage tissue and implants comprising cartilage tissue are produced in vitro starting from cells having the ability to form an extracellular cartilage matrix. Such cells are brought into a cell space (,) and are left in this cell space for producing an extracellular cartilage matrix. The cells are brought into the cell space to have a cell density of ca. 5×10,to 10,cells per cm,of cell space. The cell space (,) is at least partly separated from a culture medium space (,) surrounding the cell space by a semi-permeable wall (,) or by an open-pore wall acting as convection barrier. The open-pore wall can be designed as a plate (,) made of a bone substitute material and constituting the bottom of the cell space (,). The cells settle on such a plate (,) and the cartilage tissue growing in the cell space (,) grows into pores or surface roughness of the plate, whereby an implant forms which consists of a bone substitute plate (,) and a cartilage layer covering the plate and whereby the two implant parts are connected to each other in positively engaged manner by being grown together.