The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 29, 2001

Filed:

Mar. 12, 1998
Applicant:
Inventors:

Masahiro Oshima, Kanagawa, JP;

Norimichi Iwase, Kanagawa, JP;

Naoto Inakoshi, Kanagawa, JP;

Koichi Sugawara, Kanagawa, JP;

Misao Okitsu, Kanagawa, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; A61K 3/140 ; A61K 3/1445 ;
U.S. Cl.
CPC ...
C07D / ; C07D / ; A61K 3/140 ; A61K 3/1445 ;
Abstract

Compounds represented by the general formula (I) wherein n represents 1 or 2; R,represents, for example, a C,-C,alkyl group which may be substituted with a C,-C,cycloalkyl group or carboxyl group; R,represents hydrogen atom, a C,-C,alkyl group or other; and R,represents amino group or amidino group, whose example include trans-4-amino-[(S)-N-[(S)-2-propoxycarbonylamino-3-isopropylthio-3-methyl-butanoyl]prolyl]aminomethylcyclohexane. The compounds have potent inhibitory activity against thrombin, and are useful as anticoagulants.


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