The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2001
Filed:
Oct. 05, 1998
Nabil M Lawandy, North Kingstown, RI (US);
Spectra Science Corporation, Providence, RI (US);
Abstract
Disclosed is a method for generating an image of a selected area of tissue, the method includes steps of: (a) providing a fluorescent photosensitizer compound in combination with a hydrogen-containing solvent to the selected area of tissue; (b) generating acoustic energy for generating free radicals from the solvent; (c) reacting the free radicals with an oxalate ester to generate a key intermediate; (d) transferring chemical energy to the fluorescent photosensitizer compound from the key intermediate; (e) activating the fluorescent photosensitizer compound with the transferred energy to emit long wavelength light; and (f) detecting the long wavelength light to generate the image of the selected area of tissue. In one embodiment the oxalate ester is comprised of ester bis (2,4-dinitrophenyl) oxalate (DNPO). In one application, a selected area of living tissue is analyzed to identify an abnormality within the tissue.