The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2001
Filed:
Mar. 04, 1999
Roelof Willem Feenstra, Weesp, NL;
Cornelis Gerrit Kruse, Weesp, NL;
Martinus Theodorus Maria Tulp, Weesp, NL;
Wilma Kuipers, Weesp, NL;
Stephen Kenneth Long, Weesp, NL;
Abstract
The invention relates to a group of new piperazine and piperidine compounds having interesting pharmacological properties. It has been found that compounds of formula (a) wherein A represents a heterocyclic group of 5-7 ring atoms wherein 1-3 heteroatoms from the group O, N and S are present; R,is hydrogen or fluoro; R,is C,-alkyl, C,-alkoxy or an oxo group, and p is 0, 1 or 2; Z represents carbon or nitrogen, and the dotted line is a single bond when Z is nitrogen, and a single or double bond when Z is carbon; R,and R,independently are hydrogen or C,-alkyl; n has the value 1 or 2; R,is halogen, hydroxy, C,-alkoxy or C,-alkyl, and q is 0, 1, 2 or 3; Y is phenyl, furanyl or thienyl, which groups may be substituted with 1-3 substituents of the group hydroxy, halogen, C,-alkoxy, C,-alkyl, cyano, aminocarbonyl, mono- or di-C,-alkylaminocarbonyl; and salts thereof show high affinity for both the dopamine D,and serotonin 5-HT,receptors.