The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2001
Filed:
May. 09, 1997
John Carson, West Hartford, CT (US);
Sunjong Kwon, Newington, CT (US);
Kevin Ainger, Zurich, CH;
Daniela Avossa, Zurich, CH;
Research Corporation Technologies, Inc., Tucson, AZ (US);
Abstract
The present invention provides isolated nucleic acid molecules which comprise sequences from the 3′ UTR of myelin basic protein (MBP) mRNA. The subject isolated nucleic acid molecules confer properties such as localization, transport and increased translational efficiency of a heterologous mRNA transcript when transcribed into such mRNA. The present invention also provides vectors comprising the subject isolated nucleic acids. The vectors are useful for increasing translational efficiency of mRNA transcripts produced by a heterologous gene incorporated therein. Also provided by the present invention are methods for increasing translation of a heterologous gene. The methods comprise transforming a eukaryotic cell with at least one of the subject vectors having coding sequence for a heterologous gene. Methods for enhancing gene therapy are also provided.