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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 6224878 B1

PDFFull Text
Date of Patent:
May. 01, 2001

Filed:

Sep. 04, 1997

Mutants and vaccines of the infectious bovine rhinotracheitis virus

Applicant:
Inventors:

Patricia Leung-Tack, Villeurbanne, FR;

Isabelle Christine Marie-Andrée Legastelois, Mornant, FR;

Jean-Christophe Francis Audonnet, Lyons, FR;

Michel Emile Albert Riviere, Ecully, FR;

Assignee:

Merial, Lyons, FR;

Attorney:

Larson & Taylor

Primary Examiner:

Ali R Salimi

Int. Cl.
CPC ...
A61K 3/912 ; A61K 3/9245 ; C12N 1/500 ; C12Q 1/70 ;
U.S. Cl.
CPC ...
A61K 3/912 ; A61K 3/9245 ; C12N 1/500 ; C12Q 1/70 ;
Abstract

A recombinant virus is provided which is obtained from a BHV virus originally having the gI gene whose DNA sequence is delimited by nucleotides 172 and 1311 of SEQ ID NO:1 herein and which has been mutated by total or partial deletion and/or insertion in this region. By the mutation in this region, there is no longer any expression of the glycoprotein which has been mutated or rendered inactive, and thus animals vaccinated with these mutants do not develop antibodies against the glycoprotein and can be serologically distinguished from animals infected by field BHV-1 strains and other vaccinal strains currently used. A method of using the present recombinant virus is also provided which allows one to distinguish infected animals from vaccinated animals in a manner that has not previously been possible using presently available commercial vaccines. The invention is thus advantageous in that the mutant viruses obtained by the invention can be used as vectors for expression of various foreign genes so as to prepare useful vaccines against bovine and ruminant diseases.

Find Patent Forward Citations

Leung-Tack, Patricia. (2001). Mutants and vaccines of the infectious bovine rhinotracheitis virus (U.S. Patent No. 6224878). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6224878

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