The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 10, 2001

Filed:

Mar. 24, 1998
Applicant:
Inventors:

Donald J. Abraham, Midlothian, VA (US);

Richmond E. Danso-Danquah, Richmond, VA (US);

Telih Boyiri, Richmond, VA (US);

Changquing Wang, Richmond, VA (US);

Michael J. Gerber, Richmond, VA (US);

Stephen J. Hoffman, Englewood, CO (US);

Gajanan Joshi, Glen Allen, VA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/1185 ; A61K 3/1235 ; A61K 3/119 ;
U.S. Cl.
CPC ...
A61K 3/1185 ; A61K 3/1235 ; A61K 3/119 ;
Abstract

Chemical structures have been identified which allosterically modify pyrvate kinase and either inhibit or activate enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic processes is beneficial, such as the glycolytic pathway, all pathways which use ATP as an energy source, and all pathways which involve 2,3-diphosphoglycerate.


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