The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2001
Filed:
Nov. 12, 1996
Howard Benjamin, Lexington, MA (US);
Ling Chai, Lexington, MA (US);
Mark A. Findeis, Cambridge, MA (US);
William Goodwin, Melrose, MA (US);
Arvind Hundal, Brighton, MA (US);
David I. Israel, Concord, MA (US);
Michael Kelley, Arlington, MA (US);
Martin P. Keough, Abington, MA (US);
Kuanghui Lu, Cambridge, MA (US);
Farah Natoli, Quincy, MA (US);
Alicia Peticolas, Watertown, MA (US);
Ethan R. Signer, Cambridge, MA (US);
Malcolm L. Gefter, Lincoln, MA (US);
Praecis Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
This invention provides peptide compounds that bind to either a fibroblast growth factor (FGF) or a fibroblast growth factor receptor (FGFR) and, accordingly, are useful for modulating FGFR activity. Preferably, the FGFR is FGFR2-IIIC. Preferably, the FGF is basic FGF. Preferably the peptide compound comprises an amino acid sequence: (Y/F)-(L/F/I)-(R/D/E/S/Y/G)-(Q/L/Y)-Y-(M/L/K/R)-(L/M/D/E/N/S)-(R/L/S/T)-(L/F/M/V) (SEQ ID NO: 1). The invention further comprises pharmaceutical compositions comprising the peptide compounds of the invention and a pharmaceutically acceptable carrier. The invention still further provides methods of modulating FGFR activity using the peptide compounds of the invention.