The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2001
Filed:
Sep. 22, 1998
Applicant:
Inventors:
Gideon A. Rodan, Bryn Mawr, PA (US);
Su Jane Rutledge, East Greenville, PA (US);
Azriel Schmidt, Bryn Mawr, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 3/353 ; G01N 3/3567 ; C12P 2/106 ; C12N 1/500 ; C07K 1/00 ;
U.S. Cl.
CPC ...
G01N 3/353 ; G01N 3/3567 ; C12P 2/106 ; C12N 1/500 ; C07K 1/00 ;
Abstract
A human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.