The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2001
Filed:
Oct. 03, 1997
Applicant:
Inventors:
Alejandro A. Aruffo, Belle Mead, NJ (US);
N. Jan Chalupny, Seattle, WA (US);
Lieping Chen, Rochester, MN (US);
Robert S. Mittler, Flemington, NJ (US);
Walter W. Shuford, Redmond, WA (US);
Anthony W. Siadak, Seattle, WA (US);
Assignee:
Bristol-Myers Squibb Co., New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/9395 ; A61K 4/500 ; C07K 1/628 ;
U.S. Cl.
CPC ...
A61K 3/9395 ; A61K 4/500 ; C07K 1/628 ;
Abstract
The instant invention discloses the unexpected result that two anti-4-1BB monoclonal antibodies can inhibit both primary and secondary humoral responses to at least T-cell dependent antigens in vivo. Such antibodies provide a novel approach to immunosuppression and cancer therapy in vivo.