The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2001
Filed:
May. 11, 1998
Applicant:
Inventors:
Assignee:
NeXstar Pharmaceuticals, Inc., Boulder, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/102 ; C07H 2/104 ; C12Q 1/68 ; C12P 1/934 ;
U.S. Cl.
CPC ...
C07H 2/102 ; C07H 2/104 ; C12Q 1/68 ; C12P 1/934 ;
Abstract
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF&bgr;, PDGF and hKGF. Included in the invention are specific RNA and ssDNA ligands to TGF&bgr;1 and PDGF identified by the SELEX method. Also included in the invention are specific RNA ligands to hKGF identified by the SELEX method. Further included are RNA ligands that inhibit the interaction of TGF&bgr;1 and hKGF with their receptors and DNA ligands that inhibit the interaction of PDGF with its receptor.