The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2001
Filed:
Feb. 10, 1997
Applicant:
Inventors:
Allen I. Oliff, Gwynedd Valley, PA (US);
Gwynneth M. Edwards, Collegeville, PA (US);
Deborah D. Jones, Bala Cynwyd, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/421 ; A61K 3/845 ;
U.S. Cl.
CPC ...
C07K 1/421 ; A61K 3/845 ;
Abstract
We have modified PE,toxin by removing at least two of its four cysteine amino acid residues and have formed hybrid molecules containing modified PE,linked to a cell recognition protein that can be an antibody, a growth factor, a hormone, a lymphokine, or another polypeptide cell recognition protein for which a specific cellular receptor exists whereby the modified PE,toxin is directed to cell types having receptors for the cell recognition protein linked to the modified PE,.