The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2001
Filed:
Apr. 24, 2000
Sandra Marina Monaghan, Sandwich, GB;
David Alker, Sandwich, GB;
Christopher John Burns, Sydney, AU;
Pfizer INC, New York, NY (US);
Abstract
The present invention provides a compound of formula (I) wherein R is phenyl, C,-C,cycloalkyl or heteroaryl, each of which being optionally benzo- or C,-C,cycloalkyl-fused and optionally substituted, including in the benzo- or C,-C,cycloalkyl-fused portion, by from 1 to 3 substituents each independently selected from C,-C,alkyl, fluoro(C,-C,)alkyl, C,-C,alkoxy, fluoro(C,-C,)alkoxy, phenoxy, C,-C,alkanoyl, halo, C,-C,alkoxycarbonyl, C,-C,cycloalkyl, —S(O),(C,-C,alkyl), cyano, —NR,R,, —S(O),NR,R,, —NR,(C,-C,alkanoyl) and —CONR,R,, or R is 2,3-dihydrobenzo[b]furanyl or chromanyl; R,is H or C,-C,alkyl; W is a direct link, methylene or ethylene; X is unbranched C,-C,alkylene; Y is phenyl, naphthyl, benzyl, pyridyl, thienyl or C,-C,cycloalkyl, each of which being optionally substituted by from 1 to 3 substituents each independently selected from C,-C,alkyl, fluoro(C,-C,)alkyl, C,-C,alkoxy, fluoro(C,-C,)alkoxy, halo and cyano; Ar is phenyl, naphthyl, benzyl, thienyl, benzo[b]thienyl or indolyl, each of which being optionally substituted by from 1 to 3 substituents each independently selected from C,-C,alkyl, fluoro(C,-C,)alkyl, C,-C,alkoxy, fluoro(C,-C,)alkoxy, halo and cyano, or Ar is 1,3-benzodioxolan-4 or 5-yl or 1,4-benzodioxan-5 or 6-yl; Z,is a pharmaceutically acceptable anion; with the proviso that when W is a direct link and R is optionally fused and optionally substituted heteroaryl, said heteroaryl is linked by a ring carbon atom to the carbonyl group. The compounds are tachykinin antagonists.