The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2001
Filed:
Jan. 13, 2000
Applicant:
Inventors:
Valeria Livi, Monza, IT;
Silvano Spinelli, Monza, IT;
Marco Conti, Monza, IT;
Simonetta D'Alo', Monza, IT;
Ernesto Menta, Monza, IT;
Assignee:
Novuspharma S.p.A., Monza, IT;
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/119 ; A61K 3/1215 ; A61K 3/166 ; C07F 9/38 ;
U.S. Cl.
CPC ...
A61K 3/119 ; A61K 3/1215 ; A61K 3/166 ; C07F 9/38 ;
Abstract
The present invention relates to conjugates of 3-carboxy-4,4′-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.