The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2001
Filed:
Jan. 30, 1999
David S. Alberts, Tucson, AZ (US);
Peter H. Bartels, Tucson, AZ (US);
Other;
Abstract
A method is disclosed for quantitatively measuring the progression of a lesion toward malignant disease by digitizing images of clinical samples of biopsied lesions using a microphotometer that includes a video camera, and a computer that includes a video frame capture board. The digitized image is analyzed to locate the borders of cell nuclei within the captured video image, and one or more chromatin texture features within such nuclei are processed by the computer to arrive at a numerical value. This numerical value is compared to a monotonic progression curve that has been previously established by using the same procedure on known clinical samples ranging from normal tissue to malignant disease. The method can also be used to test the efficacy of chemopreventive drugs and treatments.