The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2001
Filed:
Oct. 20, 1997
Applicant:
Inventors:
Howard M. Johnson, Gainesville, FL (US);
Carol H. Pontzer, Silver Springs, MD (US);
Prem S. Subramaniam, Gainesville, FL (US);
Lorelie H. Villarete, Alameda, CA (US);
Jackeline Campos, Pittsburg, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/521 ; C07K 1/456 ; C07K 1/4555 ; A61K 3/821 ;
U.S. Cl.
CPC ...
C12N 1/521 ; C07K 1/456 ; C07K 1/4555 ; A61K 3/821 ;
Abstract
The invention describes a method of reducing the cytotoxicity of interferon-alpha by making defined amino acid substitutions in the N-terminal portion of the polypeptide sequence. Also described are human interferon-alpha analogs with low cytotoxicity, and therapeutic applications of the low toxicity interferon-alpha analogs.