The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2001
Filed:
Jan. 21, 1999
Applicant:
Inventors:
Michinori Kohara, Chiba, JP;
Takaji Wakita, Tokyo, JP;
Hiromichi Yonekawa, Saitama, JP;
Choji Taya, Tokyo, JP;
Izumu Saito, Tokyo, JP;
Assignee:
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 ; C12N 1/500 ; C12N 1/509 ; C12N 1/563 ; A61K 4/900 ;
U.S. Cl.
CPC ...
C12N 5/00 ; C12N 1/500 ; C12N 1/509 ; C12N 1/563 ; A61K 4/900 ;
Abstract
Transgenic mice are described which serve as a model for Hepatitis C infection. The transgenic mice contain, in their germline and somatic cells, the Hepatitis C viral fragment CN2, N24 or CR under the control of a Cre-loxP switch-expression system. Administration of Cre to the mice results in a phenotype of increased serum GTP levels, emergence of acidophilic bodies in the liver, exfoliation of hepatic cells, hypertrophy and hyperplasia of Kupffer's cells, and conglomeration of lymphocytes.