The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2001
Filed:
Dec. 22, 1999
Applicant:
Inventors:
Linda B. Couto, Pleasanton, CA (US);
Peter C. Colosi, Alameda, CA (US);
Xiaobing Qian, Alameda, CA (US);
Assignee:
Avigen, Inc., Alameda, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/500 ; A61K 4/800 ; C12N 1/563 ; C12N 1/585 ; C12N 1/586 ;
U.S. Cl.
CPC ...
A61K 3/500 ; A61K 4/800 ; C12N 1/563 ; C12N 1/585 ; C12N 1/586 ;
Abstract
The present invention provides improved viral vectors useful for the expression of genes at high levels in human cells. In particular, the present invention provides recombinant adeno-associated vectors (AAV) suitable for gene therapy. These vectors are capable of delivering nucleic acid containing constructs which result in the production of full-length therapeutic levels of biologically active Factor VIII in the recipient individual in vivo. The present invention also provides pharmaceutical compositions comprising such AAV vectors, as well as methods for making and using these constructs.