The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2001
Filed:
Sep. 21, 1998
Erica Berleth, North Tonawanda, NY (US);
M. Jane Ehrke, Lancaster, NY (US);
Srikanth S. Nadadur, Williamsville, NY (US);
Hira Gurtoo, East Amherst, NY (US);
Alicia Henn, Buffalo, NY (US);
Enrico Mihich, Buffalo, NY (US);
Health Research, Inc., Buffalo, NY (US);
Abstract
A specific, unique, natural biological factor that has the capacity to abate one or more of the toxic effects of TNF. This factor may have therapeutic potential in one or more of the diverse disease states in which TNF is known to have a causative role. The unique, approximately 27 kDa protein is designated TIP-B,. TIP-B,, when purified and added back to TNF sensitive cells, effectively ablates TNF-induced cell lysis and TNF-induced apoptosis; cytolytic effects are central to many TNF-mediated actions. The invention includes a protein designated TIP-B,purified to homogeneity. The protein has a molecular weight of about 27 kD. The protein is capable of inhibiting the action of TNF upon a cell, when said protein is introduced into extracellular medium surrounding the cell. The protein is free of sequences which interfere with normal cellular TNF binding sites and is free of sequences which directly bind to TNF. The invention further includes a method for using the protein for controlling TNF activity upon a cell.