2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart

Abstract

The invention refers to novel 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives of formula (I) having an influence on the heart and the central nervous system, furthermore pharmaceutical compositions containing the above derivatives, and a process for the preparations of the novel compounds. In formula (I) R,represents a hydrogen atom, a C,alkyl group of a phenyl group optionally substituted by 1 to 3 substituents selected from the group defined in the application, Z stands for a hydrogen atom of a C,alkoxy group, R,means a group of the formula Alk—NR,R,wherein Alk is a C,straight of branched chain alkylene group, R,and R,represent, independently, a hydrogen atom, a C,alkenyl group, a C,alkyl group optionally substituted by a substituent selected from the group defined in the application or R,and R,form together with the adjacent nitrogen atom and optionally with one or more further nitrogen and/or oxygen and/or sulfur atom(s) a 5- to 10-membered saturated heterocyclic group, optionally substituted, one of R,and R,is an amino group, while the other stands for an amino group of a 5- to 10-membered saturated heterocyclic group containing one or more nitrogen and/or oxygen and/or sulfur atom(s) and being linked through its nitrogen atom, said heterocyclic group being optionally substituted or the latter one of R,and R,means a group of formula —SR wherein R represents a C,alkyl group, a C,alkenyl group or a C,alkinyl group, wherein the alkyl group is optionally substituted by a phenyl group of a halophenyl group, and optionally one or both amino group(s) is/are substituted by 1 of 2 substituent(s) selected from the group consisting of a C,alkyl group, a C,alkenyl group, a phenyl(C,alkyl) group or a halophenyl-(C,alkyl) group.