The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2001
Filed:
Apr. 21, 1997
Applicant:
Inventors:
Robert A. Moreau, Quakertown, PA (US);
Kevin B. Hicks, Malvern, PA (US);
Assignee:
The United States of America as represented by the Secretary of Agriculture, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/156 ; A61K 3/158 ;
U.S. Cl.
CPC ...
A61K 3/156 ; A61K 3/158 ;
Abstract
The arachidonic acid-metabolizing hopanoid tetrahydroxybacteriohopane (THBH) was isolated from,and was found to inhibit soybean 15-lipoxygenase, and thus lipoxin biosynthesis, with an IC,of about 10 &mgr;M. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase (involved in prostaglandin biosynthesis) and prostaglandin H synthase, were unaffected by THBH. Subsequent studies showed that THBH was effective as an anti-inflammatory agent in topical applications.