The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2001
Filed:
Sep. 20, 1999
Applicant:
Inventor:
Michael Preiss, Wuppertal, DE;
Assignee:
Bayer Aktiengesellschaft, Leverkusen, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07B 5/500 ; C07C / ;
U.S. Cl.
CPC ...
C07B 5/500 ; C07C / ;
Abstract
The invention relates to a continuous process for the preparation of enantiomerically pure biarylketocarboxylic acids, S-phenylethylamine being employed as an auxiliary base in the resolution. Biarylketocarboxylic acids, in particular substituted biaryl-4-ketocarboxylic acids, are inhibitors of enzymes of the matrix metalloproteinases class. By inhibition of the abovementioned enzymes, it is possible, for example, to control osteoarthritis, rheumatoid arthritis and metastases.