The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2001
Filed:
Jul. 30, 1998
Anice Thigpen, Dallas, TX (US);
Hans-Ewald Hohmeier, Dallas, TX (US);
Christopher B. Newgard, Dallas, TX (US);
Roger H. Unger, Dallas, TX (US);
Michio Shimabukuro, Okinawa, JP;
Guoxun Chen, Dallas, TX (US);
Christopher J. Rhodes, Dallas, TX (US);
Sigrun R. H{umlaut over (u)}gl, Irving, TX (US);
Sharon Cousin, Irving, TX (US);
Other;
Abstract
The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic intervention of diabetes. The present invention demonstrates that MnSOD can play a protective role against cytokine killing, and provides strategies for engineering cell lines as islet surrogates for transplantation therapy of diabetes mellitus. Further, the present invention shows that &bgr;-cell destruction and dysfunction in adipogenic diabetes is mediated via fatty acids. Methods and compositions for ameliorating this disorder are provided herein.