The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2001
Filed:
Jun. 26, 1997
George Papandreou, Miami, FL (US);
Pallassana V. Narayanan, Davie, FL (US);
Cordis Corporation, Miami, FL (US);
Abstract
The preparation and use of medical devices are described. A thiol group agent is loaded onto a medical device such as a stent or a catheter. Preferably, the loading is accomplished onto a polymeric surface that had been activated by water vapor RF plasma treatment. The thiol group agent is structured to exhibit sulfhydryl groups. These sulfhydryl groups are available for interaction with NO carriers such as nitrovasodilators. This interaction can take place in situ at an in vivo location within a vascular system, for example, in which event the sulfhydryl groups would be delivered by the medical device while the NO carrier will be delivered by suitable pharmaceutical administration means. Alternatively, the NO carrier can be loaded onto the treated medical device surface at a suitable time prior to insertion of the medical device into the body, such as immediately before the initiation of a medical procedure such as stent delivery and implantation.