The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2000
Filed:
Jul. 08, 1999
Jerome L Moniot, Chester, NJ (US);
Sushil K Srivastava, Dayton, NJ (US);
William J Winter, Montgomery, NY (US);
John J Venit, North Brunswick, NJ (US);
Shankar Swaminathan, North Brunswick, NJ (US);
Keith Ramig, Orange, NJ (US);
Paul A Jass, Charles City, IA (US);
Mark D Schwinden, Holland, PA (US);
John L Dillon, Jr, East Syracuse, NY (US);
Saibaba Racha, East Syracuse, NY (US);
James Simpson, Belle Mead, NJ (US);
Chien-Kuang Chen, Marlboro, NJ (US);
Shawn K Pack, Plainsboro, NJ (US);
Bristol-Myers Squibb Co., Princeton, NJ (US);
Abstract
N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.