The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2000
Filed:
Jun. 05, 1998
Applicant:
Inventors:
Daniel Goldman, Ann Arbor, MI (US);
Mohan K Sapru, Naperville, IL (US);
Assignee:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
435325 ; 536 241 ; 536 231 ; 4353201 ; 435348 ; 435349 ; 435352 ; 435363 ; 435368 ; 435371 ;
Abstract
Methods for therapeutics and for screens are provided using a 15 bp sequence in the rat .epsilon.-subunit promoter that regulates PTPase, neuregulin and Ras-dependent gene expression. As this 15 bp sequence is necessary also for low .epsilon.-subunit gene expression in extrajunctional regions of the muscle fiber, the screens can identify agents that simultaneously and oppositely modulate expression in .epsilon.-subunit expression of synaptic and extrajunctional regions.