The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2000
Filed:
Apr. 24, 1998
Applicant:
Inventors:
Jeffrey Clayton Baker, Indianapolis, IN (US);
Andrew David Carlson, Indianapolis, IN (US);
Lihua Huang, Carmel, IN (US);
Theodore Arsay Sheliga, Indianapolis, IN (US);
Assignee:
Eli Lilly And Company, Indianapolis, IN (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; A61K / ;
U.S. Cl.
CPC ...
435212 ; 435188 ; 424 9464 ;
Abstract
The present invention is broadly directed to a method for reducing autodegradation of activated protein C during processing and purification. The present invention provides aqueous activated protein C solutions and an improved method of processing of such solutions, comprising conducting such processing at an ionic strength of greater than 150 mM and at a pH of about 5.5 to less than 6.3.