The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2000
Filed:
Jun. 23, 1997
Wayne Godfrey, White Bear Lake, MN (US);
Edgar G Engleman, Atherton, CA (US);
David Buck, Santa Clara, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Becton Dickinson and Company, Franklin Lakes, NJ (US);
Abstract
The invention provides ligands and fragments thereof to a receptor on the surface of activated CD4.sup.+ T-cells. An exemplary ligand is designated ACT-4-L-h-1. Preferred fragments include purified extracellular domains of ligands. The invention also provides humanized and human antibodies to the ligand. The invention further provides methods of using the ligand and the antibodies in treatment of diseases and conditions of the immune system. The invention also provides methods of monitoring activated CD4.sup.+ T-cells using the ligands or fragments thereof.