The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2000
Filed:
Jul. 20, 1998
Applicant:
Inventors:
C P Pathak, Austin, TX (US);
Mark A Moore, Austin, TX (US);
Assignee:
Sulzer Carbomedics Inc., Austin, TX (US);
Primary Examiner:
Int. Cl.
CPC ...
G01N / ; C12N / ; A61K / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
435 405 ; 435-11 ; 435 4052 ; 435181 ; 530356 ; 530402 ; 530816 ;
Abstract
Collagen-containing tissue is cross-linked to provide tissue suitable for use in production of bioprosthetic devices. A cross-linking agent is used having an aliphatic component containing about 8 to 40 carbon atoms and two collagen-reactive groups such as isocyanate, epoxy or n-hydroxysuccinimide. The cross-linking agent may be produced by dimerizing fatty acids, and modifying carboxylic acid group of the fatty acids before or after dimerization to contain collagen-reactive groups. The cross-linked tissue has desirable mechanical and biocompatibility features and a reduced susceptibility to calcification.