The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2000
Filed:
Aug. 15, 1997
Applicant:
Inventors:
James Inglese, Dayton, NJ (US);
Kenneth C Appell, Skillman, NJ (US);
Philippe Samama, Lawrenceville, NJ (US);
Ilana L Stroke, Cranbury, NJ (US);
Jonathan J Burbaum, Cranbury, NJ (US);
Assignee:
Pharmacopeia, Inc., Cranbury, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N / ;
U.S. Cl.
CPC ...
435-71 ; 435-72 ; 435-724 ; 435-78 ; 435-79 ; 435-792 ; 435-793 ; 435-795 ; 530324 ; 530402 ;
Abstract
The present invention encompasses polypeptides that comprise a chemokine receptor binding sequence and are useful in determining the affinity of a compound for a chemokine receptor. Substitution of one of the amino acids of the C-terminal region of the polypeptide with a cysteine enables the polypeptide to be detectably labelled without loss of receptor binding activity and without the problems inherent in radioiodine labelling. Methods for use of the polypeptides in competitive binding assays are also disclosed.