The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2000
Filed:
Oct. 28, 1998
Michael J Natan, State College, PA (US);
Christine Keating, State College, PA (US);
The Penn State Research Foundation, University Park, PA (US);
Abstract
A substrate for surface enhanced Raman scattering (SERS) is described in which the analyte is deliberately sandwiched between a colloidal metal nanoparticle and the SERS substrate. In a first embodiment, the analyte is a protein, and the sandwich comprises a protein:Au colloid complex adsorbed to an aggregated Ag sol. Another embodiment concerns a protein:Ag complex, adsorbed to an aggregated Ag sol. In another embodiment, a protein:Au colloid complex is covalently or non-covalently attached to a macroscopic SERS-active substrate. In yet another embodiment, the colloidal nanoparticle is stabilized by a polymeric additive. In yet another embodiment, detection is accomplished at extremely low analyte concentrations. In a final embodiment, control of analyte orientation with respect to the SERS substrate is demonstrated.