The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2000
Filed:
May. 06, 1998
Sei-ichi Tanuma, Hachioji-shi, Tokyo 192-03, JP;
Other;
Abstract
The present invention relates to novel DNases .alpha., .beta. and .gamma. capable of selectively cleaving the linker sites of chromatin DNA. The present invention also relates to novel DNase .gamma. involved in fragmentation of chromatin DNA in apoptosis. The present invention further relates to amino acid sequence of DNase .gamma., DNA encoding said enzyme, nucleotide sequence of said DNA, recombinant vector containing said DNA, transformant containing said recombinant vector, production method of DNase .gamma. comprising culture of said transformant, and antibody having affinity for said DNase .gamma., precursor thereof and the amino acid sequence of fragments thereof. The DNase .gamma. of the present invention takes part in the control system of apoptosis, and effectively contributes to the development of medications for the prevention, treatment and diagnosis of apoptosis-inhibitory or promotive diseases such as cancer, autoimmune diseases and viral infections. In addition, the DNases .alpha. and .beta. of the present invention increase upon viral infection to cleave viral DNA, and are useful for the development of therapeutic agents for viral infections.