The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2000
Filed:
Jun. 06, 1995
Applicant:
Inventors:
Deborah DeFeo-Jones, Lansdale, PA (US);
Dong-Mei Feng, Harleysville, PA (US);
Victor M Garsky, Blue Bell, PA (US);
Raymond E Jones, Lansdale, PA (US);
Allen I Oliff, Gwynedd Valley, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
530322 ; 530324 ; 530326 ; 530328 ; 530329 ; 514 12 ; 514 13 ; 514 14 ; 514 15 ; 514 16 ; 514 17 ;
Abstract
Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.