The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2000
Filed:
May. 24, 1999
Applicant:
Inventors:
William Heggie, Palmela, PT;
Jose Galindro, Lisboa, PT;
Pedro Santos, Queluz, PT;
Luis Carvalho, Seixal, PT;
Assignee:
Hovione Inter Ltd., , PT;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C25B / ;
U.S. Cl.
CPC ...
205437 ; 205438 ; 205446 ;
Abstract
The present invention refers to a process for the preparation of 4-(des-dimethylamino)-tetracyclines, which compounds have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis in an aqueous solution at acidic pH, in the presence of an adequate electrolyte. A direct electrical current with a potential of 0.5-1.5 volts is applied between two convenient electrodes until the reaction is complete. The 4-(des-dimethylamino)-tetracyclines are isolated by extraction with an organic solvent.