The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2000
Filed:
May. 14, 1999
Eun Mi Hur, Kyonggi-do, KR;
Young Bong Choi, Kyonggi-do, KR;
Changwon Park, Kyonggi-do, KR;
Jongsung Lee, Seoul, KR;
Dongsu Park, Kyonggi-do, KR;
Yungdae Yun, Seoul, KR;
Keun Hyeung Lee, Seoul, KR;
Jong-Eun Oh, Seoul, KR;
Soon Choul Ahn, Taejon-si, KR;
Hyun Sun Lee, Taejon-si, KR;
Jong Sok Ahn, Taejon-si, KR;
Soo Il Jung, Kyonggi-do, KR;
Abstract
The present invention relates to use of rosmarinic acid and/or derivatives thereof as immunosuppressive agents and/or as inhibitor of SH2 domain function. Disclosed in the present invention is that rosmarinic acid and derivatives thereof specifically inhibit the binding of ligand peptides to Lck SH2 domain, disturb the Lck-mediated signal transduction in T cells, also inhibit cytoline gene expression, and suppress immune responses in the transplanted tissue. These activities of rosmarinic acid and derivatives thereof support their applicability to treatment, prevention and/or diagnosis of graft rejection, GVHD, autoimmune diseases, inflammatory diseases, etc.