The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2000
Filed:
Mar. 24, 1998
Applicant:
Inventors:
Haya Lorberboum-Galski, Jerusalem 97875, IL;
Shai Yarkoni, Kfar-Saba 44395, IL;
Ahmi Ben-Yehudah, D.N. Harei Yehuda 90852, IL;
Irina Marianovsky, Jerusalem, IL;
Amotz Nechushtan, Ramat Hsharon 47223, IL;
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N / ;
U.S. Cl.
CPC ...
435-723 ; 435-71 ; 435-72 ; 436 64 ; 530398 ;
Abstract
The present invention relates to methods for cancer diagnosis using a chimeric toxin. In particular, the invention relates to the use of a chimeric toxin composed of gonadotropin releasing hormone (GnRH) and Pseudomonas exotoxin A (PE) to detect a tumor-associated epitope expressed by human adenocarcinomas. Mutated GnRH-PE molecules that bind but do not kill tumor cells are exemplified.