The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2000
Filed:
Sep. 10, 1996
Applicant:
Inventors:
Marcel Loetscher, Koeniz, CH;
Bernhard Moser, Stettlen, CH;
Assignee:
Theodor-Kocher Institute, Bern, CH;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N / ; C12N / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
435-72 ; 435-71 ; 435325 ; 530350 ; 530351 ; 5303879 ;
Abstract
The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.