The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2000
Filed:
Dec. 16, 1998
Alan S Waggoner, Pittsburgh, PA (US);
Ratnakar B Mujumdar, Pittsburgh, PA (US);
Carnegie Mellon University, Pittsburgh, PA (US);
Abstract
Disclosed are analogues of trimethine cyanine dyes which are useful for imparting fluorescent properties to target materials by covalent and non-covalent association. The compounds have the following general formula: ##STR1## optionally substituted by groups R.sup.2 -R.sup.9 wherein groups R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are attached to the rings containing X and Y or, optionally are attached to atoms of the Z.sup.a and Z.sup.b ring structures and groups R.sup.1 -R.sup.9 are chosen to provide desired solubility, reactivity and spectral properties to the fluorescent compounds; A is selected from O, S and NR.sup.11 where R.sup.11 is the substituted amino radical: ##STR2## where R' is selected from hydrogen, a C.sub.1-4 alkyl and aryl and R' is selected from C.sub.1-18 alkyl, aryl, heteroaryl, an acyl radical having from 2-7 carbon atoms, and a thiocarbamoyl radical; Z.sup.a and Z.sup.b each represent a bond or the atoms necessary to complete one, two fused or three fused aromatic rings each ring having five or six atoms, selected from carbon atoms and, optionally, no more than two oxygen, nitrogen and sulphur atoms.