The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2000
Filed:
Feb. 05, 1997
Applicant:
Inventors:
Kari Alitalo, Espoo, FI;
Vladimir Joukov, Helsinki, FI;
Assignee:
Helsinki University Licensing, Ltd., Helsinki, FI;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ;
U.S. Cl.
CPC ...
435 694 ; 530350 ; 530399 ; 4353201 ; 435325 ; 536 2351 ; 514-2 ; 514 12 ;
Abstract
Provided are purified and isolated VEGF-C cysteine deletion variants that bind to Flt4 receptor tyrosine kinase (VEGFR-3) but demonstrate reduced binding (relative to VEGF-C) to kdr receptor tyrosine kinase (VEGFR-2); polynucleotides encoding the polypeptide; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the foregoing.