The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2000
Filed:
Jun. 18, 1999
Hanspeter Mettler, Visp, CH;
Paul Hanselmann, Brig-Glis, CH;
Lonza AG, Gampel/Valais, CH;
Abstract
A process for the preparation of formylimidazoles of the general formula: or its tautomers, in which R.sup.1 is hydrogen or alkyl, and R.sup.2 is hydrogen, halogen or alkyl. In a first stage, an imidazole derivative of the general formula: ##STR1## or its tautomers, in which R.sup.1 and R.sup.2 are as defined above, is converted, by introducing an amino protective group, into an imidazole derivative of the general formula: ##STR2## or its tautomers, in which R.sup.3 is an amino protective group. Such derivative is formylated in a second stage in the presence of an organometallic compound and a suitable electrophile to give an imidazole derivative of the general formula: ##STR3## or its tautomers, in which R.sup.1, R.sup.2 and R.sup.3 are as defined above. Then, in a third stage, the end product of the formula I is obtained by cleaving off the amino protective group.