The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2000
Filed:
Jun. 02, 1994
David S Terman, Pebble Beach, CA (US);
Jay L Stone, Aptos, CA (US);
Pharmacia AB, Stockholm, SE;
Abstract
Staphylococcal enterotoxins obtained by secretion from Staphylococcus aureus, by expression of enterotoxins in other bacteria or cells, or by chemical mutagenic treatment of Staphlococcus aureus strains are used in treatment of cancer as tumoricidal agents. Enterotoxins A, B, C, D, E and toxic shock toxin (TSST-1) can be administered via simple intravenous injection or in the form of adjuvants such as pluronic triblock copolymers. Enterotoxins may also be used ex-vivo to induce mitogenesis, enlarge and enrich a tumoricidal T-cell population. Streptococcus pyrogenic exotoxins which have structural and functional homology to the enterotoxins, are also useful in tumoricidal treatment. Chemically derivatized enterotoxins as well as synthetic or genetically prepared polypeptides having structural homology to the native enterotoxins are also useful in this application.