The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2000
Filed:
Dec. 22, 1998
Applicant:
Inventors:
Avi J Ashkenazi, San Mateo, CA (US);
Steven M Chamow, San Mateo, CA (US);
Timothy P Kogan, Sugar Land, TX (US);
Assignee:
Genetech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C07D / ;
U.S. Cl.
CPC ...
530351 ; 530352 ; 530359 ; 530380 ; 5303871 ; 5303891 ; 5303892 ; 5303911 ; 5303913 ; 5303915 ; 5303917 ; 5303919 ; 548544 ; 548546 ; 548547 ; 548548 ; 548549 ; 424 851 ; 4241781 ; 4241791 ; 4241941 ; 42419511 ;
Abstract
The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.