The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2000

Filed:

Apr. 03, 1998
Applicant:
Inventors:

Gary A Rogers, Santa Barbara, CA (US);

Peter Johnstrom, Skondal, SE;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ;
U.S. Cl.
CPC ...
51421003 ; 51421206 ; 5142295 ; 5142305 ; 540300 ; 540301 ; 540521 ; 544 89 ; 544 95 ;
Abstract

Compounds based on the benzoxazine ring system that are remarkably more potent than corresponding benzoyl piperidines for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof, and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.


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