The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2000
Filed:
Aug. 25, 1998
Gregg L Semenza, Towson, MD (US);
The Johns Hopkins University School of Medicine, Baltimore, MD (US);
Abstract
Substantially purified stable human hypoxia-inducible factor-1.alpha. (sHIF-1.alpha.) mutein is provided. Polynucleotides encoding stable human hypoxia-inducible factor-1.alpha. mutein are also provided. A method is provided for treating a hypoxia-related tissue damage in a subject by administering to the subject a therapeutically effective amount of a sHIF-1.alpha. mutein or a nucleotide sequence including an expression control sequence operatively linked to a polynucleotide encoding a stable hypoxia-inducible factor-1.alpha. mutein. Formulations are provided for the administration of stable human hypoxia inducible factor-1.alpha. (HIF-1.alpha.) polypeptide or a polynucleotide encoding stable human hypoxia inducible factor-1.alpha. (HIF-1.alpha.) to a patient having hypoxia-related tissue damage.