The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2000
Filed:
Mar. 10, 1998
Masanori Baba, Kagoshima, JP;
Minoru Ono, Tokyo, JP;
Kaken Shoyaku Co., Ltd., Tokyo, JP;
Abstract
This invention relates to an NF-.kappa.B activity inhibitor which contains alkaloids originated from a plant belonging to the genus Stephania of the family Menspermaceae, derivatives thereof and salts thereof, as the active components, to an agent for use in the treatment and prevention of diseases upon which the NF-.kappa.B activity inhibiting action is effective and to an inhibitor of the expression of related genes. Since said active components exert an action to inhibit transcription of DNA having an NF-.kappa.B recognition sequence by inhibiting the activity of NF-.kappa.B, the drug of the present invention can inhibit expression of genes of certain substances such as cytokines, inflammatory cytokine receptor antagonists, MHC class I, MHC class II, .beta.2 microglobulin, immunoglobulin light chain, serum amyloid A, angiotensinogen, complement B, complement C4, C-myc gene, HIV, SV40, CMV, adenovirus and the like, so that the inventive drug is useful in treating and/or preventing various diseases in which these substances are taking roles.