The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2000
Filed:
Jul. 29, 1996
Applicant:
Inventors:
Arnold J Reuser, Rotterdam, NL;
Ans T Van der Ploeg, Poortugaal, NL;
Frank R Pieper, Utrecht, NL;
Martin Ph Verbeet, Amsterdam, NL;
Assignees:
Pharming B.V., Leiden, NL;
The Universiteit Leiden, Leiden, NL;
Academic Hospital, Rotterdam, NL;
Eramus Universiteit, Rotterdam, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K / ; A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
800 14 ; 800-7 ; 800 21 ; 119D / ; 4241571 ; 424535 ; 424 9461 ;
Abstract
The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.