The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2000

Filed:

Nov. 25, 1997
Applicant:
Inventors:

John Wityak, West Grove, PA (US);

Chu-Biao Xue, Hockessin, DE (US);

Thais Motria Sielecki-Dzurdz, Newark, DE (US);

Richard Eric Olson, Wilmington, DE (US);

William Frank Degrado, Moylan, PA (US);

Gary Avonn Cain, Wilmington, DE (US);

Douglas Guy Batt, Wilmington, DE (US);

Donald Pinto, Newark, DE (US);

Munir Alwan Hussain, Wilmington, DE (US);

Shaker Ahmed Mousa, Lincoln University, PA (US);

Assignee:

Dupont Pharmaceuticals Company, Wilmington, DE (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
5142278 ; 5142368 ; 514269 ; 514307 ; 514326 ; 514340 ; 514365 ; 514378 ; 514379 ; 514380 ; 544 60 ; 544111 ; 544137 ; 544140 ; 544297 ; 544298 ; 544322 ; 544333 ; 546141 ; 546143 ; 546209 ; 546275 ; 548146 ; 548240 ; 548243 ; 548248 ;
Abstract

This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.


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