The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2000
Filed:
Feb. 12, 1999
Daniel Sedmak, Columbus, OH (US);
Daniel Miller, Hilliard, OH (US);
Brian Rahill, Columbus, OH (US);
Yingxue Zhang, Columbus, OH (US);
Ohio State Research Foundation, Columbus, OH (US);
Abstract
A method for reducing levels of JAK 1 and thereby blocking the signal transduction pathways that are employed by IFN-.alpha., IFN-.beta., and IFN-.gamma. is provided. In one embodiment the method comprises the steps of: providing a cytomegalovirus (CMV) gene product selected from the group consisting of the CMV immediate early gene (IE) products, the CMV early gene (E) products, and combinations thereof; and introducing the CMV gene product or products into cells at levels sufficient to decrease the levels of JAK 1 in the cell. In another embodiment the method comprises the steps of providing a DNA molecule that comprises a CMV IE gene, a CMV E gene, or combinations thereof; introducing the DNA molecule into the cell; and inducing the expression of CMV IE and E genes in the cell, wherein the expression of products encoded by the CMV IE and CMV E genes decreases the levels of JAK 1 in the cell.