The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2000
Filed:
Jul. 08, 1998
Robert H Allen, Baton Rouge, LA (US);
R Carl Herndon, Jr, Baton Rouge, LA (US);
Kannappan C Chockalingam, Baton Rouge, LA (US);
W Dirk Klobucar, Baton Rouge, LA (US);
Gary D Focht, Baton Rouge, LA (US);
Tse-Chong Wu, Baton Rouge, LA (US);
Gary D Heidebrecht, Orangeburg, SC (US);
Joseph D McLean, Orangeburg, SC (US);
Yaping Zhong, Columbia, SC (US);
Thorsten W Brockmann, Columbia, SC (US);
Ronny W Lin, Baton Rouge, LA (US);
William J Layman, Jr, Baton Rouge, LA (US);
Ranjit K Roy, Baton Rouge, LA (US);
Albemarle Corporation, Richmond, VA (US);
Abstract
Palladium-catalyzed arylation of an olefin (e.g., ethylene) with an aromatic halide (e.g., 2-bromo-6-methoxynaphthalene, m-bromobenzophenone, or 4-isobutyl-1-bromobenzene) is conducted in specified media. After a special acid or base phase separation procedure, palladium-catalyzed carbonylation of the olefinically-substituted aromatic intermediate is conducted in specified media using CO and water or an alcohol to form arylalkylcarboxylic acid or ester or substituted arylalkylcarboxylic acid or ester (e.g., racemic 2-(6-methoxy-2-naphthyl)propionic acid, 2-(3-benzoylphenyl)propionic acid, or 2-(4-isobutylphenyl)propionic acid). Catalyst recovery procedures enabling recycle of catalyst residues and efficient recovery of amine hydrogen halide scavenger and solvent used in the arylation reaction are described, as well as novel, highly efficient methods of conducting the carbonylation reaction. The technology is economical and suitable for use on an industrial scale whereby reaction mixtures can be efficiently separated into the desired component mixtures without need for excessive capital investment or tedious, time-consuming operations. High yields of high purity products can be achieved.